Treatment of Primperan (metoclopramide) overdose generally involves symptomatic and supportive care. There is no specific antidote for metoclopramide intoxication; however, agents like diphenhydramine and benztropine may be useful in controlling extrapyramidal reactions like extreme restlessness, involuntary movements, and uncontrollable speech. Symptoms of metoclopramide overdose are generally self-limiting and usually subside within 24 hrs. Appropriate therapy should be instituted if hypotension or excessive sedation occurs. Methaemoglobinaemia (higher methemoglobin) should be treated with methylene blue. Haemodialysis or peritoneal dialysis is unlikely to enhance the elimination of metoclopramide.