Lendormin (brotizolam) has been shown in animal studies to be a very high potency benzodiazepine, and it may be the most potent benzodiazepine used on humans. Although further studies need to be done to confirm this. Lethal dose of benzodiazepines is massive that is why there are no definite reports regarding this. Toxicological studies of brotizolam were first recorded at doses of 7-10 mg/kg up to 400mg/kg or more, most of which were reversible. So far there are no serious side effects reported to date and the most frequently observed adverse experiences are drowsiness, headache, and dizziness. Mild rebound insomnia may occur in some patients when treatment is stopped. Benzodiazepines are usually not fatal when taken alone in overdose, but those with underlying conditions for example respiratory disease or when benzodiazepines are taken in combination with other CNS depressant drugs can result in death.