I was on Flexeril for more than three years for my FM. However, I noticed that it was not as effective as it used to be. So, I decided to come off the drug. After a few days of not taking it, I felt my symptoms coming up again, so I took a dose of Flexeril and I noticed a very good improvement in my condition. I have started taking the drug again. I think you need to take a break from the drug and not take it for sometime in order fro the drug to remain effective. I highly recommend this drug to other people with FM.