Google Epiduo. It's a new acne cream that combines the generic Differin, adapalene (1%), and benzoyl peroxide (2.5%). BP 2.5% is the same ingredient and dosage found in the Proactiv cleanser, so yes it is safe to combine, but always check with your dr. You just don't want to use Proactiv's toner which contains glycolic acid. I've used Proactiv for 10+ years and it has always worked really well for me. I recently added adapalene to my regimen to combat wrinkles - my physician recommended it and she uses both products herself. Proactiv may not be effective for everyone, but it works great for me.