I am a 38 year old male being treated for Fibromyalgia and depression and suffer excruciating pain and tiredness. On research I found that Provigil was a good drug for this and on the recommendation of my psychiatrist started on the pill. I have been taking this medication for over two years and have not suffered any incidents of depression since and my feeling or tiredness is 60 % gone. It has made a fantastic difference in me. Update: By and large Provigil has stood by me in spite of the highs and lows that everyone goes through, but it is still as effective as before. Update: I see that Provigil occupies top ranking among drugs for Depression. It is not at all surprising considering the fact that it has been really very effective for me.