I consume Effexor 25 mg qid or may be 5 times per day for about 2 weeks when I had PMS and I am very much impressed with this drug because previously from past 15 years I consumed many anti-depressants but there was no improvement and they did not have prolonged action. Before I used to take Zoloft and had good results with that except few sexual problems but finally developed resistance to this moreover I did not have any of such problems with Effexor as I am using it since 3 years. I have a small doubt whether I need to increase the dosage for more better results and I am not pretty sure whether it helps me better or worsens my condition actually I can say one thing that it is the best medication for persons who are drug resistant to few medicines though the drug action may vary from person to person. For example I cannot stand for Prozac though few of friends really like that drug so I may be a little wrong in my opinion but always suggest everyone having this problem to try Effexor first. The one and only complication with Effexor is persons may become addicted to this drug and though you stop consuming it the withdrawal signs are severe however there is no other choice for me I have to take any anti-depressant lifelong because previously I was very much depressive and had a thought of even committing suicide so now my condition is better than before and I wish it maintains the same action throughout my life.